ONO-9517601 is a potent, orally active, selective and CNS penetrant dual TREK-1/TREK-2 inhibitor (TREK-1 IC 50 = 0.067 μM, TREK-2 IC 50 = 0.23 μM). ONO-9517601 displays robust efficacy in an MK-801 ( HY-15084B ) challenge rat novel object recognition (NOR) paradigm. ONO-9517601 can be used for research on neurological and cognitive disorders.
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