CD28-IN-2 is a selective CD28-B7 interaction ( IC 50 : 22.4 μM) inhibitor that binds directly to CD28 , with a K d value of 24.1 μM. CD28-IN-2 inhibits CD28-driven immune activation and blocks T cell costimulation. CD28-IN-2 can be used for the study of antitumor immunity and immune-related disorders.
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