UCB1244283 is a synaptic vesicle glycoprotein 2A ( SV2A ) allosteric modulator. UCB1244283 binds to a secondary ligand-binding site in SV2A and enhances orthosteric ligand engagement when the orthosteric site is occupied, by stabilizing the occluded state and slowing ligand dissociation. UCB1244283 shows a clear protective effect against both tonic and clonic convulsions in sound-sensitive mice. UCB1244283 can be used for epilepsy research.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Epilepsy | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Synaptic Vesicle Proteins
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