KRAS G12C-IN-74 is an orally active, selective KRAS G12C inhibitor with a target IC 50 of 43.18 nM. KRAS G12C-IN-74 induces G0/G1 cell cycle arrest and apoptosis in KRAS G12C -mutant cancer cells. KRAS G12C-IN-74 is applicable for the research of KRAS G12C -mutant pancreatic cancer , colorectal cancer and lung cancer .
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