Prexasertib lactate

Overview

Prexasertib lactate (LY2606368 lactate) is the lactate form of Prexasertib ( HY-18174 ). Prexasertib lactate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K i of 0.9 nM and an IC 50 of <1 nM. Prexasertib lactate inhibits CHK2 (IC 50 =8 nM) and RSK1 (IC 50 =9 nM). Prexasertib lactate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis . Prexasertib lactate shows potent anti-tumor activity.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Checkpoint Kinase (Chk) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-18174H
• CAS No.: 2781996-46-9
• Molecular Formula: C21H25N7O5
• Molecular Weight: 455.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source