FGFR3-IN-12

Overview

FGFR3-IN-12 is a selective fibroblast growth factor receptor 3 (FGFR3) inhibitor with an IC 50 of 6.8 nM. FGFR3-IN-12 shows an IC 50 of 19.2 nM against FGFR3 V555M and an IC 50 of 16.9 nM against TNK1 (Thirty-eight Negative Kinase 1) . FGFR3-IN-12 inhibits cancer cells proliferation and induces caspase -mediated apoptosis . FGFR3-IN-12 exhibits antitumor activity in bladder cancer xenografts mice models. FGFR3-IN-12 can be used for the research of cancer , such as bladder cancer .

Application

Products | Products > Disease Areas > Bladder Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > FGFR | Products > Signaling Pathways > TNK1 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-181752
• CAS No.: 3127143-52-3
• Molecular Formula: C26H30N8O2
• Molecular Weight: 486.57
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source