LMK-235 is a potent and selective HDAC4/5 inhibitor, inhibits HDAC5 , HDAC4 , HDAC6 , HDAC1 , HDAC2 , HDAC11 and HDAC8 , with IC 50 s of 4.22 nM, 11.9 nM, 55.7 nM, 320 nM, 881 nM, 852 nM and 1278 nM, respectively, and is used in cancer research.
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