Latanoprostene bunod

Overview

Latanoprost ene bunod (NCX116; LBN) is a nitric oxide-releasing prostaglandin F 2 α analog. Latanoprost ene bunod is a prodrug that, upon instillation into the eye, is hydrolyzed by corneal esterases into two active metabolites: Latanoprost ( HY-B0577 ) and NO. Latanoprost activates the prostaglandin FP receptor to increase the outflow of aqueous humor through the uveoscleral pathway. NO increases aqueous humor drainage through the trabecular meshwork pathway, achieving synergistic enhancement targeting the dual pathways of aqueous humor outflow. Latanoprost ene bunod can be used in research related to open-angle glaucoma and ocular hypertension.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Visual System Disease | Products > Disease Areas > Glaucoma | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Prostaglandin Receptor

Product Information

• Catalog No.: HY-19518
• CAS No.: 860005-21-6
• Molecular Formula: C27H41NO8
• Molecular Weight: 507.62
• Purity: 99.75%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.92 mM); Clear solution
• Availability: In-stock

Source

Original product source