SCH-23390 is a dopamine D1-like receptor antagonist (with K i values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline ( HY-B0726A ) and strychnine, and is used in research on neurological disorders related to the dopamine system.
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