OTS964 is an orally active, high affinity and selective TOPK inhibitor with an IC 50 of 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 , which binds to CDK11B with a K d of 40 nM.
Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > TOPK | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis
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