STO-609 is a selective and cell-permeable inhibitor of the Ca 2+ /calmodulin-dependent protein kinase kinase ( CaM-KK ), with K i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC 50 ~0.02 g/ml.
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