Burixafor hydrobromide

Overview

Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC 50 of 7.4. Burixafor hydrobromide inhibits the binding of CXCL12 to CXCR4 , antagonizes CXCL12 -induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34 + hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood. Burixafor hydrobromide can be used for research on autologous hematopoietic stem cell transplantation ( ASCT ).

Application

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Product Information

• Catalog No.: HY-19867A
• CAS No.: 1191450-19-7
• Molecular Formula: C27H51N8O3P.5/2HBr
• Molecular Weight: 769.01
• Purity: 99.70%
• Storage: -20°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: 20 mg/mL (26.01 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source