Baclofen hydrochloride, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA B receptor (GABA B R) agonist. Baclofen hydrochloride mimics the action of GABA and produces slow presynaptic inhibition through the GABA B receptor. Baclofen hydrochloride has high blood brain barrier penetrance. Baclofen hydrochloride has the potential for muscle spasticity research.
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