Tetrabenazine mesylate

Overview

Tetrabenazine (Ro 1-9569) mesylate is a brain-penetrant and orally active VMAT2 -selective ligand with human VMAT2 K i 100 nM. Tetrabenazine mesylate binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine mesylate weakly blocks dopamine D2 receptors , and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine mesylate can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Monoamine Transporter | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-B0590E
• CAS No.: 804-53-5
• Molecular Formula: C20H31NO6S
• Molecular Weight: 413.53
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source