Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT 2A receptor ( K i of 0.6 nM) and dopamine D 2 receptor ( K i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT 1A receptor ( K i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research .
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