CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC 50 s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 , respectively. G2019S LRRK2 -induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC 50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity.
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