Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator , acts as an orally active biguanide antidiabetic agent . Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer , et al).
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