Lurasidone metabolite 14326 is a minor active metabolite of Lurasidone ( HY-B0032A ) generated via metabolism by CYP3A4 . Lurasidone metabolite 14326 shares similar receptor-binding properties with Lurasidone , acting as an antagonist of the dopamine D2 receptor ( dopamine D2 receptor ), an antagonist of the serotonin 5-HT2A and 5-HT7 receptors ( 5-HT2A and 5-HT7 receptor ), and a partial agonist of the serotonin 5-HT1A receptor. Lurasidone metabolite 14326 can be used in the research of schizophrenia and bipolar depression.
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