Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd . Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase ( AChE ) activity, increasing choline acetyltransferase ( ChAT ) activity, and elevating levels of acetylcholine ( Ach ) in the hippocampus and frontal cortex.
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