Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum . Dihydromethysticin inhibits carboxylesterase 1 ( K i = 68.2 μM) and CYP2A5 . Dihydromethysticin upregulates NLRC3 and induces Apoptosis . Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma.
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