Tanshinone IIA anhydride

Overview

Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza , acts as an inhibitor of human carboxylesterase ( CE ). Tanshinone IIA anhydride has a K i value of 1.9 nM against hCE1 and a K i value of 1.4 nM against hiCE . Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase , and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Carboxylesterase (CES)

Product Information

• Catalog No.: HY-N10686
• CAS No.: 61077-78-9
• Molecular Formula: C19H18O4
• Molecular Weight: 310.34
• Purity: 97.03%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source