Naamidine J

Overview

Naamidine J is an imidazole-type alkaloids discovered in a sponge . Naamidine J inhibits inflammation by binding to the protein CSE1L ( K D = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α , IL-1β , and IL-6 , and upregulates anti-inflammatory factors such as CD206 and Arg-1 . Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors.

Application

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Product Information

• Catalog No.: HY-N14001
• CAS No.: 2227550-73-2
• Molecular Formula: C25H27N5O5
• Molecular Weight: 477.51
• Purity: 99.41%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source