Coccinine ((-)-Coccinine) is a weak inhibitor of SERT ( IC 50 : 196.3 μM; K i : 106.8 μM) and P-gp ( IC 50 : 0.96 mM). Coccinine exhibits significant anti-tumor activity against various cancer cell lines, such as breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549). Coccinine can be used in the research of tumors and neurological diseases.
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