1-Isomangostin hydrate is a semi-synthetic cyclized xanthone derivative of α-mangostin ( HY-N0328 ), exhibiting weak cytotoxicity against HT-29 human colon cancer cells (ED 50 > 20 μM). 1-Isomangostin hydrate can be used in research on colon cancer and other tumors. The natural precursor of 1-isomangostin hydrate, α-mangostin, is derived from the stem of Cratoxylum cochinchinense (a plant of the Cratoxylum genus in the Clusiaceae family).
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