Deacetyltanghinin is a selective inhibitor targeting Na + /K + ATPase , acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na + /K + ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2 -PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer . At the same time, attention should be paid to the regulation of its cardiotoxicity.
Products | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Na+/K+ ATPase | Products > Signaling Pathways > Prostaglandin Receptor | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis
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