13'-Carboxy-δ-tocopherol is a metabolite of long-chain vitamin E.13'-Carboxy-δ-tocopherol exhibits antiproliferative properties in cancer cells. 13'-Carboxy-δ-tocopherol activates caspase-3 , caspase-9 , causes PARP-1 cleavage, reduces mitochondrial membrane potential, increases ROS formation, and drives apoptosis .13'-Carboxy-δ-tocopherol can be used for the research of hepatocellular carcinoma.
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