Siaresinolic acid is a compound found in the leaves of Sabicea grisea . Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel , inhibits leukocyte influx, plasma leakage, and proinflammatory mediator ( TNF-α , IL-1β ) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain.
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