Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus , has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS , COX-2 , prostaglandin E2 ( PGE2 ) and nuclear factor-kappa B ( NF-κB ) expression in murine macrophage cells.
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