Swertiajaponin is a tyrosinase inhibitor , forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase , with an IC 50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity.
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