(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium .(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits K i values of 1.25 nM and 1.84 μM for binding to α4β2- and α7-type nicotinic receptors in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [ 3 H]-dopamine release from rat striatal synaptosomes ( EC 50 =134 nM). (±)-Anatoxin A fumarate has toxic effect on fish.
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