Vanicoside B is a phenylpropanoyl sucrose derivative, can be isolated from the herb Persicaria dissitiflora . Vanicoside B targets cyclin-dependent kinase 8 ( CDK8 ) and exhibits anti-tumor activity. The potential mechanism is Vanicoside B blocks CDK8 -mediated signaling pathways and decreases the expression of epithelial-mesenchymal transition proteins, so that it leads to cell cycle arrest and apoptosis .
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