(S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes ( SOD , CAT ) and ROS , reduces the levels of oxidative stress markers ( MDA , AChE ), reduces the secretion of proinflammatory cytokines ( IL-1β , IL-4 , IL-6 , IL-10 ), and downregulates NLRP3 . (S)-(+)-Carvone increases the activities of caspase -8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer . (S)-(+)-Carvone improves memory and arthritis.
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