9,10-Phenanthrenequinone

Overview

9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Claudin

Product Information

• Catalog No.: HY-W014507
• CAS No.: 84-11-7
• Molecular Formula: C14H8O2
• Molecular Weight: 208.21
• Purity: 99.72%
• Storage: Store at room temperature 3 years. In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1 mg/mL (4.80 mM); Clear solution
• Availability: In-stock

Source

Original product source