Z-Gly-Gly-Phe-OH is a substrate for pepsin and thermolysin . Z-Gly-Gly-Phe-OH has an IC 50 of 15.8 μM for open sodium channels under pepsin catalysis. Z-Gly-Gly-Phe-OH forms peptide bonds with amine components (such as H-Leu-NHPh) through enzyme-catalyzed condensation reactions, and is active as an intermediate in peptide synthesis.
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