PDGFRα kinase inhibitor 2 (compound 1), an Imatinib ( HY-15463 ) analogue, is a covalent and irreversible kinase inhibitor with IC 50 s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt.
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