Norbixin is an orally active natural product with multiple activities such as retinal protection and oxidative stress regulation. Norbixin scavenges ROS , chelates metal ions, regulates plasmid and genomic DNA breakage, inhibits H 2 O 2 -induced mutagenesis, activates PPAR-α , modulates lipid levels, restores or regulates antioxidant enzyme activity, and alters NO levels. Norbixin prevents A2E accumulation and protects photoreceptor cells and retinal pigment epithelial cells. Norbixin is a derivative of Bixin ( HY-N6884 ). Norbixin can be used in research related to diseases such as macular degeneration and diabetes, and also serves as a natural textile dye.
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