1,2,3,6,7,8-Hexachlorodibenzofuran

Overview

1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase ( AHH ) and ethoxyresorufin-O-deethylase ( EROD ) in H-4-II-E rat hepatoma cells ( EC 50 s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats ( EC 50 s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-W762015
• CAS No.: 57117-44-9
• Molecular Formula: C12H2Cl6O
• Molecular Weight: 374.86
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source