Ethyl 3,4-dihydroxybenzoate- 13 C 3

Overview

Ethyl 3,4-Dihydroxybenzoate- 13 C 3 (Protocatechuic acid ethyl ester- 13 C 3 ) is the 13 C-labeled Ethyl 3,4-dihydroxybenzoate ( HY-W016409 ). Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor ( HIF ) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema.

Application

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Product Information

• Catalog No.: HY-W778057
• CAS No.: 1330195-40-8
• Molecular Formula: C613C3H10O4
• Molecular Weight: 185.15
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source