AZM198

Overview

AZM198 is an orally active myeloperoxidase ( MPO ) inhibitor. AZM198 irreversibly inactivates MPO ( IC 50 =0.015 μM) via covalent binding to the heme prosthetic group, preferentially targets extracellular MPO activity, and reduces neutrophil extracellular trap formation, reactive oxygen species production and degranulation. AZM198 increases the fibrous cap thickness of atherosclerotic plaques, reduces lesion area, ameliorates hepatic steatosis and fibrosis in non-alcoholic steatohepatitis, and alleviates proteinuria and inflammatory infiltration associated with glomerulonephritis. AZM198 also decreases circulating levels of high-sensitivity Cardiac Troponin I and IL-1β , and mitigates endothelial cell injury. Therefore, AZM198 is suitable for research on various MPO-related diseases, including atherosclerotic cardiovascular disease , myocardial infarction, ischemic stroke, non-alcoholic steatohepatitis and crescentic glomerulonephritis.

Application

Products | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Genitourinary Inflammation | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Ischemic Stroke | Products > Disease Areas > Nephritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Glutathione Peroxidase

Product Information

• Catalog No.: HY-W996116
• CAS No.: 1933460-23-1
• Molecular Formula: C14H13ClN4OS
• Molecular Weight: 320.80
• Purity: 98.40%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.67 mg/mL (5.21 mM); Clear solution
• Availability: In-stock

Source

Original product source