Tambiciclib

Overview

Tambiciclib (GFH009, JSH-009) is an orally active, highly potent and selective CDK9 inhibitor ( IC 50 = 1 nM), demonstrating >200-fold selectivity over other CDKs, >100-fold selectivity over DYRK1A / B , and excellent selectivity over 468 kinases/mutants. Tambiciclib demonstrates potent in vitro and in vivo antileukemic efficacy in acute myeloid leukemia (AML) mouse models by inhibiting RNA Pol II phosphorylation, downregulating MCL1 and MYC , and inducing apoptosis . Tambiciclib can be used for AML research.

Application

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Product Information

• Catalog No.: HY-X0009
• CAS No.: 2247481-08-7
• Molecular Formula: C25H35ClN6O2S
• Molecular Weight: 519.10
• Purity: 99.68%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 5 mg/mL (9.63 mM); Clear solution
• Availability: In-stock

Source

Original product source