venetoclax

venetoclax
  • CAS No.:1257044-40-8
  • Formula:C45H50ClN7O7S
  • M.W.:868.44
  • Solvent:10mM in DMSO

Overview

Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, a protein commonly overexpressed in cancer cells, to induce programmed death of CLL cells. Venetoclax is used as a second-line treatment of chronic lymphocytic leukemia (CLL).

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Bcl-2 Family

Product Information

  • Catalog No.: B0084-462638
  • CAS No.: 1257044-40-8
  • Molecular Formula: C45H50ClN7O7S
  • Molecular Weight: 868.44
  • Solubility: 10mM in DMSO

Source

Original product source


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