RGB-286638 Free base

Overview

RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | CDK

Product Information

• Catalog No.: B0084-463330
• CAS No.: 784210-88-4
• Molecular Formula: C29H35N7O4
• Molecular Weight: 545.63
• Purity: >98%

Source

Original product source