SAR-405

Overview

SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM, Kd = 1.5 nM) without disrupting other PI3K isoforms and mTOR (IC50 > 10,000 nM). Concomitant inhibition of Vps34 and mTOR, with SAR405 and mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | PI3K

Product Information

• Catalog No.: B2693-482215
• CAS No.: 1523406-39-4
• Molecular Formula: C19H21ClF3N5O2
• Molecular Weight: 443.85
• Storage: Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -42°C for long term (months to years).

Source

Original product source