3-MPPI is a GPCR ligand with high selectivity for α 1 -adrenergic receptor , with a K i value of 0.21 nM for α 1 -adrenergic receptor and 50 nM for 5-HT 1 A receptor. 3-MPPI modulates the α 1 -adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia.
Products | Products > Disease Areas > Hypertension | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Anxiety or Fear-Related Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Adrenergic Receptor | Products > Signaling Pathways > G protein-coupled Bile Acid Receptor 1
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