Tasidotin

Overview

Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase ( PREP ) inhibitor, with an IC 50 of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase . Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer , leukemia, melanoma, central nervous system malignancies and various solid tumors.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Prolyl Endopeptidase (PREP)

Product Information

• Catalog No.: HY-106021
• CAS No.: 192658-64-3
• Molecular Formula: C32H58N6O5
• Molecular Weight: 606.85
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source