NCO-700 sulfate is a dual cathepsin B and calcium-activated neutral protease ( CANP ) inhibitor with IC 50 values of 0.8 and 46 μM, respectively. NCO-700 sulfate reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 sulfate also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis . NCO-700 sulfate can be used to study myocardial ischemia and refractory hormone-independent tumors.
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