Difenamizole

Overview

Difenamizole (Pasalin) is an orally active pyrazole non-steroidal anti-inflammatory agent and pain inhibitor, which capable of crossing the blood-brain barrier. Difenamizole inhibits the release of catecholamines by monoaminergic neurons, reduces the concentrations of dopamine metabolites and normetanephrine (NE) in the striatum, and thereby regulates the levels of dopamine and norepinephrine in the brain. Difenamizole is not only antagonized by dopamine in the brain, but also exerts synergistic effects with Oxidopamine (6-OHDA) (HY-B1081/A), Phenoxybenzamine ( HY-B0431 ), Reserpine ( HY-N0480 ), and other agents. Difenamizole inhibits conditioned, emotional and aggressive behaviors in rodents, and can be used in studies of pain and related neurobehaviors.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-106470
• CAS No.: 20170-20-1
• Molecular Formula: C20H22N4O
• Molecular Weight: 334.42
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source