PHA-793887 hydrochloride

Overview

PHA-793887 hydrochloride is a CDK inhibitor (with IC 50 values of 8 nM for Cdk2 , 60 nM for Cdk1 , 62 nM for Cdk4 , 138 nM for Cdk9 ). PHA-793887 hydrochloride inhibits purified GSK3β ( IC 50 79 nM). PHA-793887 hydrochloride reduces the phosphorylation level of nucleophosmin/ cdc6 , induces G1/G2/M phase arrest, and triggers Apoptosis by activating Caspase-3 . PHA-793887 hydrochloride exhibits anticancer activity against leukemia. PHA-793887 hydrochloride can be used in research related to acute leukemia, chronic myeloid leukemia, and advanced/metastatic solid tumors.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > GSK-3

Product Information

• Catalog No.: HY-11001A
• CAS No.: 718630-60-5
• Molecular Formula: C19H32ClN5O2
• Molecular Weight: 397.94
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source