NSC 23925B

Overview

NSC 23925B is a P-glycoprotein (P-gp) inhibitor, as well as the most biologically active isomer of NSC23925 ( HY-19626 ), which reverses and prevents P-glycoprotein-mediated multidrug resistance in cancer cells. NSC 23925B shows weak inhibition against most CYP450 enzymes ( IC 50 > 10 μM), and exhibits moderate inhibitory activity against CYP2B6 and CYP2D6 with IC 50 values of 8.589 μM and 1.407 μM, respectively. NSC 23925B can be used for the research of multidrug-resistant cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Others | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > P-glycoprotein | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Drug Isomer

Product Information

• Catalog No.: HY-117593
• CAS No.: 1369591-04-7
• Molecular Formula: C22H26Cl2N2O2
• Molecular Weight: 421.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source