RO0505124

Overview

RO0505124 is a selective CDK4 inhibitor with an IC 50 of 20 nM. RO0505124 reversibly binds the ATP pocket of the kinase. RO0505124 induces G1 phase arrest in cancer cells via reduced retinoblastoma protein (Rb) phosphorylation, blocking S phase progression. RO0505124 exhibits anti-proliferative activity against various cancer cells. RO0505124 delays mitosis , induces aberrant mitosis with lagging chromosomes, driving mitotic slippage and formation of multinucleated or micronucleated cells. RO0505124 inhibits G2/M phase accumulation of survivin and borealin . RO0505124 can be used for the research of cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Survivin

Product Information

• Catalog No.: HY-118447
• CAS No.: 443913-79-9
• Molecular Formula: C23H25N5O3S
• Molecular Weight: 451.55
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source